Amitriptyline + Pregabalin is used in the treatment of neuropathic pain.
Amitriptyline + Pregabalin is a combination of two medicines: Amitriptyline and Pregabalin. Amitriptyline is a tricyclic antidepressant which increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Together, they relieve neuropathic pain (pain from damaged nerves). Pregabalin is an alpha 2 delta ligand which decreases pain by modulating calcium channel activity of the nerve cells.
SIDE EFFECTS :
Constipation, Weight gain, Sleepiness, Dizziness, Tiredness, Blurred vision, Dryness in mouth, Increased heart rate, Orthostatic hypotension (sudden lowering of blood pressure on standing), Difficulty in urination, Uncoordinated body movements.