Pregabalin + Nortriptyline + Methylcobalamin is used in the treatment of neuropathic pain.
Pregabalin is an alpha 2 delta ligand which decreases pain by modulating calcium channel activity of the nerve cells. Nortriptyline is a tricyclic antidepressant which increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Methylcobalamin is a form of vitamin B which helps in the production of myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells. Together, they relieve neuropathic pain (pain from damaged nerves).
SIDE EFFECTS :
Constipation, Weight gain, Orthostatic hypotension (sudden lowering of blood pressure on standing), Increased heart rate, Dizziness, Sleepiness, Tiredness, Blurred vision, Dryness in mouth, Difficulty in urination, Uncoordinated body movements.